EXPERIMENTAL JUSTIFICATION OF THE PREVENTION OF PERIODONTAL BONE TISSUE DESTRUCTION IN OVARIOECTOMIZED RATS WITH CALCIUM-CONTAINING ADDITIVES

Purpose. Study of periodontoprotective properties preventive complexes based on calcium, quercetin, vitamins, macro- and microelements in ovariectomized rats with alimentary deficiency protein calcium. Materials methods. The study was conducted 32 female which pathology periodontal bone tissue simulated due to hipoestrogenicity; as well the prevention said biologically active calcium citrate from shells Black Sea oysters "Minerol". Hypoestrogenicity caused by bilateral ovariectomy, negative effect further complicated a diet low content protein. After 5 months, animals were removed experiment; degree atrophy alveolar process determined drugs; acid alkaline phosphatases, elastase, catalase MDA homogenate process. Results. combination ovariectomy an inferior characteristic inflammatory-dystrophic changes jaws, are expressed increase activity catalase, homogenate. Also, under condition pathology, process, phosphatases observed, indicates violation mineralization processes. Prophylactic administration complex additive "Minerol" showed pronounced osteoprotective effect, consisted decrease reduction markers resorption peroxidation lipids.